问题补充：
-- - Alison, I’m sorry. I can’t come to the wedding with you tomorrow morning.
-- ?
-- My grandma was severely ill, so I have to stay in the hospital to look after her.
A. How is it
B. How come
C. So what
D. What’s the problem
答案：
A. How is it
(答案→)B. How come
C. So what
D. What’s the problem
解析：这题考查交际用语：How come怎么回事？So what那又怎样？ What’s the problem问题是什么？，根据句意：--对不起，Alison，每天早晨我不能和你参加婚礼了。--怎么了？--我奶奶病的厉害，我要在医院照顾她。选B。
